The publications of the members of Eng4Life.
2023
Piano, Raffaelle De; Caccavo, Diego; Lamberti, Gaetano; Remaut, Katrien; Seynaeve, Hanne; Barba, Anna Angela
A New Productive Approach and Formulative Optimization for Curcumin Nanoliposomal Delivery Systems Journal Article
In: Pharmaceutics, vol. 15, iss. 3, no. 959, 2023, ISSN: 19994923.
Abstract | Links | BibTeX | Tags: anticancer, antioxidant activity, curcumin, nanoliposomes, nanotechnologies, nutraceuticals, simil-microfluidic technology
@article{Piano}2023b,
title = {A New Productive Approach and Formulative Optimization for Curcumin Nanoliposomal Delivery Systems},
author = {Raffaelle {De Piano} and Diego Caccavo and Gaetano Lamberti and Katrien Remaut and Hanne Seynaeve and Anna Angela Barba},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151381874&doi=10.3390%2fpharmaceutics15030959&partnerID=40&md5=fceef78253390aceb67f23b8ff583eb8},
doi = {10.3390/pharmaceutics15030959},
issn = {19994923},
year = {2023},
date = {2023-03-16},
urldate = {2023-03-16},
journal = {Pharmaceutics},
volume = {15},
number = {959},
issue = {3},
abstract = {The use of natural resources and the enhancing of technologies are outlining the strategies of modern scientific-technological research for sustainable health products manufacturing. In this context, the novel simil-microfluidic technology, a mild production methodology, is exploited to produce liposomal curcumin as potential powerful dosage system for cancer therapies and for nutraceutical purposes. Through simil-microfluidic technology, based on interdiffusion phenomena of a lipid-ethanol phase in an aqueous flow, massive productions of liposomes at nanometric scale can be obtained. In this work, studies on liposomal production with useful curcumin loads were performed. In particular, process issues (curcumin aggregations) were elucidated and formulation optimization for curcumin load was performed. The main achieved result has been the definition of operative conditions for nanoliposomal curcumin production with interesting loads and encapsulation efficiencies.},
keywords = {anticancer, antioxidant activity, curcumin, nanoliposomes, nanotechnologies, nutraceuticals, simil-microfluidic technology},
pubstate = {published},
tppubtype = {article}
}
The use of natural resources and the enhancing of technologies are outlining the strategies of modern scientific-technological research for sustainable health products manufacturing. In this context, the novel simil-microfluidic technology, a mild production methodology, is exploited to produce liposomal curcumin as potential powerful dosage system for cancer therapies and for nutraceutical purposes. Through simil-microfluidic technology, based on interdiffusion phenomena of a lipid-ethanol phase in an aqueous flow, massive productions of liposomes at nanometric scale can be obtained. In this work, studies on liposomal production with useful curcumin loads were performed. In particular, process issues (curcumin aggregations) were elucidated and formulation optimization for curcumin load was performed. The main achieved result has been the definition of operative conditions for nanoliposomal curcumin production with interesting loads and encapsulation efficiencies.
2017
Bochicchio, Sabrina; Lamberti, Gaetano; Barba, Anna Angela
Phenomenological and Formulation Aspects in Tailored Nanoliposome Production Book Chapter
In: Liposomes, Chapter 2, IntechOpen, 2017.
Abstract | Links | BibTeX | Tags: cell‐mimetic system, gene therapy, liposomal iron, Liposome, nanoliposomes delivery systems, nutraceuticals, personalized carriers, simil‐microfluidic approach, ultrasonic size reduction
@inbook{Bochicchio2017b,
title = {Phenomenological and Formulation Aspects in Tailored Nanoliposome Production},
author = {Sabrina Bochicchio and Gaetano Lamberti and Anna Angela Barba},
url = {https://www.intechopen.com/books/liposomes/phenomenological-and-formulation-aspects-in-tailored-nanoliposome-production},
doi = {10.5772/intechopen.68157},
year = {2017},
date = {2017-10-25},
booktitle = {Liposomes},
publisher = {IntechOpen},
chapter = {2},
abstract = {Liposomes as cell‐mimetic system have attracted wide attention of researchers in various branches of the drug delivery topic as they can be highly functionalized and personalized, thus solving the major drawbacks of bioactive molecules linked to their low stability, limited membrane permeability, short half‐life and low bioavailability. The development of sustainable processes able to produce ad hoc liposomes in a rapid manner through the use of not‐laboured techniques, avoiding drastic conditions, is of great relevance for the industrial sector. In this chapter, two novel liposome production processes, the ultrasound‐assisted thin‐film hydration and the simil‐microfluidic techniques sharing the same size reduction/homogenization preparative step, are presented. The phenomenological aspects involved in vectors constitution through the duty cycle sonication process (bilayer rupture/vesicles formation mechanisms) and through the simil‐microfluidic approach (intubated flows interdiffusion mechanisms) are described. Finally, two applications as case histories involving the use of the developed techniques for relevant classes of active molecule delivery are described. In particular, a pharmaceutical application concerns the encapsulation of short‐interfering RNA (siRNA) molecule, used for gene therapy, inside cationic nanoliposomes, and a nutraceutical application consists in the production of ferrous sulphate anionic liposomal formulations with improved features compared to those already present on the market.},
keywords = {cell‐mimetic system, gene therapy, liposomal iron, Liposome, nanoliposomes delivery systems, nutraceuticals, personalized carriers, simil‐microfluidic approach, ultrasonic size reduction},
pubstate = {published},
tppubtype = {inbook}
}
Liposomes as cell‐mimetic system have attracted wide attention of researchers in various branches of the drug delivery topic as they can be highly functionalized and personalized, thus solving the major drawbacks of bioactive molecules linked to their low stability, limited membrane permeability, short half‐life and low bioavailability. The development of sustainable processes able to produce ad hoc liposomes in a rapid manner through the use of not‐laboured techniques, avoiding drastic conditions, is of great relevance for the industrial sector. In this chapter, two novel liposome production processes, the ultrasound‐assisted thin‐film hydration and the simil‐microfluidic techniques sharing the same size reduction/homogenization preparative step, are presented. The phenomenological aspects involved in vectors constitution through the duty cycle sonication process (bilayer rupture/vesicles formation mechanisms) and through the simil‐microfluidic approach (intubated flows interdiffusion mechanisms) are described. Finally, two applications as case histories involving the use of the developed techniques for relevant classes of active molecule delivery are described. In particular, a pharmaceutical application concerns the encapsulation of short‐interfering RNA (siRNA) molecule, used for gene therapy, inside cationic nanoliposomes, and a nutraceutical application consists in the production of ferrous sulphate anionic liposomal formulations with improved features compared to those already present on the market.