October 17, 2019

Bioadhesive liposomes
Continuous process for coating liposomial vectors with polymer

The “ Bioadhesive liposomes” project consists of the production of nano-liposomal vectors coated with bioadhesive polymers for nutraceutical applications. Since 2019 Eng4Life owns the patent Continuous process for coating liposomial vectors with polymer.

The patent can be consulted at the following link.

The production technique of Eng4Life for liposomes is SMF – Simil Microfluidic that can be used to polymeric coating of the nanoliposomes vectors to produce shell-core nanostructures.

In the nutraceutical field, shell-core structures can be used for the dosing of micronutrients, bringing three main advantages:

1)

Increase in the residence time of the molecule on the site of action

2)

Improvement of the bioavailability of the encapsulated molecule

3)

Increased paracellular permeability

There are several techniques that can be used for the superficial polymeric coating of nanoliposomes, such as the dripping method (Drop-wise); Reverse-Phase Evaporation (REV); Improved Supercritical Reverse-Phase Evaporation (ISCRPE); etc …

These techniques present problems:

The SMF technique used by Eng4Life is a rapid and continuous process that guarantees:

To demonstrate its effectiveness, the SMF method was compared with the drop-wise method, as shown in the following image, the coating made with the SMF method returns shell-core particles with a thick, smooth and homogeneous polymeric surface (C2 ) those obtained with the drop-wise method show a very thin, rough and irregular coating (B2).

Here are some of the publications on the subject made by Eng4life members.

2019

Barba, Anna Angela; Bochicchio, Sabrina; Bertoncin, Paolo; Lamberti, Gaetano; Dalmoro, Annalisa

Coating of Nanolipid Structures by a Novel Simil-Microfluidic Technique: Experimental and Theoretical Approaches Journal Article

Coatings, 9 (8), pp. 491, 2019.

Abstract | Links | BibTeX

Dalmoro, Annalisa; Bochicchio, Sabrina; Lamberti, Gaetano; Bertoncin, Paolo; Janssens, Barbara; Barba, Anna Angela

Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology Journal Article

RSC Advances, 9 , pp. 19800-19812, 2019.

Abstract | Links | BibTeX

2018

Bochicchio, Sabrina; Dalmoro, Annalisa; Bertoncin, Paolo; Lamberti, Gaetano; Moustafine, Rouslan I; Barba, Anna Angela

Design and production of hybrid nanoparticles with polymeric-lipid shell–core structures: conventional and next-generation approaches Journal Article

RSC Advances, 8 , pp. 34614–34624, 2018.

Abstract | Links | BibTeX

Dalmoro, Annalisa; Bochicchio, Sabrina; Nasibullin, Shamil F; Bertoncin, Paolo; Lamberti, Gaetano; Barba, Anna Angela; Moustafine, Rouslan I

Polymer-lipid hybrid nanoparticles as enhanced indomethacin delivery systems Journal Article

European Journal of Pharmaceutical Sciences, 121 , pp. 16-28, 2018.

Abstract | Links | BibTeX